Combined Aurora kinase A (AURKA) and WEE1 inhibition demonstrates synergistic antitumor effect in squamous cell carcinoma of the head and neck

PURPOSE: Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC) commonly bear disruptive mutations in TP53, resulting in treatment resistance. In these patients, direct targeting of p53 has not been successful, but synthetic lethal approaches have promise. Although Aurora...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Clin Cancer Res
मुख्य लेखकों: Lee, Jong Woo, Parameswaran, Janaki, Sandoval-Schaefer, Teresa, Eoh, Kyung Jin, Yang, Dong-hua, Zhu, Fang, Mehra, Ranee, Sharma, Roshan, Gaffney, Stephen G., Perry, Elizabeth B., Townsend, Jeffrey P., Serebriiskii, Ilya G., Golemis, Erica A., Issaeva, Natalia, Yarbrough, Wendell G., Koo, Ja Seok, Burtness, Barbara
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2019
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548643/
https://ncbi.nlm.nih.gov/pubmed/30755439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0440
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