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The role and targeting of Aurora kinases in head and neck cancer

Controlled activation of the Aurora kinases regulates mitotic progression in normal cells. Overexpression and hyperactivation of the Aurora-A and -B kinases play a leading role in tumorigenesis, inducing aneuploidy and genomic instability. In squamous cell carcinomas of the head and neck (SCCHN), ov...

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Detalhes bibliográficos
Main Authors: Mehra, Ranee, Serebriiskii, Ilya G., Burtness, Barbara, Astsaturov, Igor, Golemis, Erica A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139969/
https://ncbi.nlm.nih.gov/pubmed/23993387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(13)70128-1
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