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The role and targeting of Aurora kinases in head and neck cancer
Controlled activation of the Aurora kinases regulates mitotic progression in normal cells. Overexpression and hyperactivation of the Aurora-A and -B kinases play a leading role in tumorigenesis, inducing aneuploidy and genomic instability. In squamous cell carcinomas of the head and neck (SCCHN), ov...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4139969/ https://ncbi.nlm.nih.gov/pubmed/23993387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(13)70128-1 |
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