Oncogenic kinase inhibition limits Batf3-dependent dendritic cell development and antitumor immunity

Gastrointestinal stromal tumor (GIST) is driven by an activating mutation in the KIT proto-oncogene. Using a mouse model of GIST and human specimens, we show that intratumoral murine CD103(+)CD11b(−) dendritic cells (DCs) and human CD141(+) DCs are associated with CD8(+) T cell infiltration and diff...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Medina, Benjamin D., Liu, Mengyuan, Vitiello, Gerardo A., Seifert, Adrian M., Zeng, Shan, Bowler, Timothy, Zhang, Jennifer Q., Cavnar, Michael J., Loo, Jennifer K., Param, Nesteene J., Maltbaek, Joanna H., Rossi, Ferdinand, Balachandran, Vinod, DeMatteo, Ronald P.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547861/
https://ncbi.nlm.nih.gov/pubmed/31000683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180660
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