Mitochondrial inhibition augments the efficacy of imatinib by resetting the metabolic phenotype of gastrointestinal stromal tumor

PURPOSE: Imatinib dramatically reduces GIST (18)F-FDG uptake, providing an early indicator of treatment response. Despite decreased glucose internalization, many GIST cells persist, suggesting that alternative metabolic pathways are used for survival. The role of mitochondria in imatinib-treated GIS...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Vitiello, Gerardo A., Medina, Benjamin D., Zeng, Shan, Bowler, Timothy G., Zhang, Jennifer Q., Loo, Jennifer K., Param, Nesteene J., Liu, Mengyuan, Moral, Alec J., Zhao, Julia N., Rossi, Ferdinand, Antonescu, Cristina R., Balachandran, Vinod P., Cross, Justin R., DeMatteo, Ronald P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815929/
https://ncbi.nlm.nih.gov/pubmed/29246941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2697
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