Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Acute myeloid leukemia (AML) is the most common acute leukemia in adults. More than half of older AML patients fail to respond to cytotoxic chemotherapy, and most responders relapse with drug-resistant disease. Failure to achieve complete remission can be partly attributed to the drug resistance adv...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Lipid Res
Hauptverfasser: Tan, Su-Fern, Dunton, Wendy, Liu, Xin, Fox, Todd E., Morad, Samy A. F., Desai, Dhimant, Doi, Kenichiro, Conaway, Mark R., Amin, Shantu, Claxton, David F., Wang, Hong-Gang, Kester, Mark, Cabot, Myles C., Feith, David J., Loughran, Thomas P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547629/
https://ncbi.nlm.nih.gov/pubmed/30962310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M091876
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge