Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Acute myeloid leukemia (AML) is the most common acute leukemia in adults. More than half of older AML patients fail to respond to cytotoxic chemotherapy, and most responders relapse with drug-resistant disease. Failure to achieve complete remission can be partly attributed to the drug resistance adv...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Tan, Su-Fern, Dunton, Wendy, Liu, Xin, Fox, Todd E., Morad, Samy A. F., Desai, Dhimant, Doi, Kenichiro, Conaway, Mark R., Amin, Shantu, Claxton, David F., Wang, Hong-Gang, Kester, Mark, Cabot, Myles C., Feith, David J., Loughran, Thomas P.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547629/
https://ncbi.nlm.nih.gov/pubmed/30962310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M091876
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