Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-κB-dependent P-glycoprotein upregulation

Acute myeloid leukemia (AML) is the most common acute leukemia in adults. More than half of older AML patients fail to respond to cytotoxic chemotherapy, and most responders relapse with drug-resistant disease. Failure to achieve complete remission can be partly attributed to the drug resistance adv...

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Pubblicato in:J Lipid Res
Autori principali: Tan, Su-Fern, Dunton, Wendy, Liu, Xin, Fox, Todd E., Morad, Samy A. F., Desai, Dhimant, Doi, Kenichiro, Conaway, Mark R., Amin, Shantu, Claxton, David F., Wang, Hong-Gang, Kester, Mark, Cabot, Myles C., Feith, David J., Loughran, Thomas P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547629/
https://ncbi.nlm.nih.gov/pubmed/30962310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M091876
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