A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication

Replication of sufficient mitochondrial DNA (mtDNA) is essential for maintaining mitochondrial functions in mammalian cells. During mtDNA replication, RNA primers must be removed before the nascent circular DNA strands rejoin. This process involves mitochondrial RNase H1, which removes most of the R...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Wu, Chyuan-Chuan, Lin, Jason L J, Yang-Yen, Hsin-Fang, Yuan, Hanna S
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547421/
https://ncbi.nlm.nih.gov/pubmed/30949702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz241
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