Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor

Biomedical applications of nucleic acid aptamers are limited by their rapid degradation in biological fluids and generally demand tedious post-selection modifications that might compromise binding. One possible solution to warrant biostability is to directly evolve chemically modified aptamers from...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Eremeeva, Elena, Fikatas, Antonios, Margamuljana, Lia, Abramov, Mikhail, Schols, Dominique, Groaz, Elisabetta, Herdewijn, Piet
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Chemical Biology and Nucleic Acid Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547419/
https://ncbi.nlm.nih.gov/pubmed/30968117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz252
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