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Single-stranded regions modulate conformational dynamics and ATPase activity of eIF4A to optimize 5′-UTR unwinding

Eukaryotic translation initiation requires unwinding of secondary structures in the 5′-untranslated region of mRNA. The DEAD-box helicase eIF4A is thought to unwind structural elements in the 5′-UTR in conjunction with eIF4G and eIF4B. Both factors jointly stimulate eIF4A activities by modulation of...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Nucleic Acids Res
Päätekijät: Andreou, Alexandra Zoi, Harms, Ulf, Klostermeier, Dagmar
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6547412/
https://ncbi.nlm.nih.gov/pubmed/30997503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz254
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