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A conformational change in the helicase core is necessary but not sufficient for RNA unwinding by the DEAD box helicase YxiN
Cooperative binding of ATP and RNA to DEAD-box helicases induces the closed conformation of their helicase core, with extensive interactions across the domain interface. The bound RNA is bent, and its distortion may constitute the first step towards RNA unwinding. To dissect the role of the conforma...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715247/ https://ncbi.nlm.nih.gov/pubmed/19474341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp397 |
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