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Single-stranded regions modulate conformational dynamics and ATPase activity of eIF4A to optimize 5′-UTR unwinding
Eukaryotic translation initiation requires unwinding of secondary structures in the 5′-untranslated region of mRNA. The DEAD-box helicase eIF4A is thought to unwind structural elements in the 5′-UTR in conjunction with eIF4G and eIF4B. Both factors jointly stimulate eIF4A activities by modulation of...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6547412/ https://ncbi.nlm.nih.gov/pubmed/30997503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz254 |
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