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eIF4G stimulates the activity of the DEAD box protein eIF4A by a conformational guidance mechanism

The activity of eIF4A, a key player in translation initiation, is regulated by other translation factors through currently unknown mechanisms. Here, we provide the necessary framework to understand the mechanism of eIF4A’s regulation by eIF4G. In solution, eIF4A adopts a defined conformation that is...

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Detalhes bibliográficos
Main Authors: Hilbert, Manuel, Kebbel, Fabian, Gubaev, Airat, Klostermeier, Dagmar
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064780/
https://ncbi.nlm.nih.gov/pubmed/21062831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1127
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