Dimethyl fumarate dosing in humans increases frataxin expression: A potential therapy for Friedreich’s Ataxia

Friedreich’s Ataxia (FA) is an inherited neurodegenerative disorder resulting from decreased expression of the mitochondrial protein frataxin, for which there is no approved therapy. High throughput screening of clinically used drugs identified Dimethyl fumarate (DMF) as protective in FA patient cel...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jasoliya, Mittal, Sacca, Francesco, Sahdeo, Sunil, Chedin, Frederic, Pane, Chiara, Brescia Morra, Vincenzo, Filla, Alessandro, Pook, Mark, Cortopassi, Gino
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546270/
https://ncbi.nlm.nih.gov/pubmed/31158268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217776
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