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Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans
The induction of mitochondrial biogenesis could potentially alleviate mitochondrial and muscle disease. We show here that dimethyl fumarate (DMF) dose-dependently induces mitochondrial biogenesis and function dosed to cells in vitro, and also dosed in vivo to mice and humans. The induction of mitoch...
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| 發表在: | Hum Mol Genet |
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| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6251607/ https://ncbi.nlm.nih.gov/pubmed/28460056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx167 |
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