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Putative Structural Rearrangements Associated with the Interaction of Macrocyclic Inhibitors with Norovirus 3CL Protease
Human noroviruses are the primary cause of outbreaks of acute gastroenteritis worldwide. The problem is further compounded by the current lack of norovirus-specific antivirals or vaccines. Noroviruses have a single-stranded, positive sense 7–8 kb RNA genome which encodes a polyprotein precursor that...
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| Udgivet i: | Proteins |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6545144/ https://ncbi.nlm.nih.gov/pubmed/30883881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25682 |
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