Structure-Based Exploration and Exploitation of the S(4) Subsite of Norovirus 3CL Protease in the Design of Potent and Permeable Inhibitors

Human noroviruses are the primary cause of epidemic and sporadic acute gastroenteritis. The worldwide high morbidity and mortality associated with norovirus infections, particularly among the elderly, immunocompromised patients and children, constitute a serious public health concern. There are curr...

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Publicado no:Eur J Med Chem
Main Authors: Galasiti Kankanamalage, Anushka C., Kim, Yunjeong, Rathnayake, Athri D., Damalanka, Vishnu C., Weerawarna, Pathum M., Doyle, Sean T., Alsoudi, Amer F., Padmasankha Dissanayake, D. M., Lushington, Gerald H., Mehzabeen, Nurjahan, Battaile, Kevin P., Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501333/
https://ncbi.nlm.nih.gov/pubmed/27914364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.11.027
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