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Putative Structural Rearrangements Associated with the Interaction of Macrocyclic Inhibitors with Norovirus 3CL Protease

Human noroviruses are the primary cause of outbreaks of acute gastroenteritis worldwide. The problem is further compounded by the current lack of norovirus-specific antivirals or vaccines. Noroviruses have a single-stranded, positive sense 7–8 kb RNA genome which encodes a polyprotein precursor that...

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Detalhes bibliográficos
Publicado no:Proteins
Main Authors: Galasiti Kankanamalage, Anushka C., Weerawarna, Pathum M., Rathnayake, Athri D., Kim, Yunjeong, Mehzabeen, Nurjahan, Battaile, Kevin P., Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6545144/
https://ncbi.nlm.nih.gov/pubmed/30883881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25682
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