Structure-guided Design, Synthesis and Evaluation of Oxazolidinone-based Inhibitors of Norovirus 3CL Protease

Acute nonbacterial gastroenteritis caused by noroviruses constitutes a global public health concern and a significant economic burden. There are currently no small molecule therapeutics or vaccines for the treatment of norovirus infections. A structure-guided approach was utilized in the design of a...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Damalanka, Vishnu C., Kim, Yunjeong, Galasiti Kankanamalage, Anushka C., Rathnayake, Athri D., Mehzabeen, Nurjahan, Battaile, Kevin P., Lovell, Scott, Nguyen, Harry Nhat, Lushington, Gerald H., Chang, Kyeong-Ok, Groutas, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737831/
https://ncbi.nlm.nih.gov/pubmed/29227928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.12.014
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