HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression

Histone deacetylase 5 (HDAC5) and HDAC9 are class IIa HDACs that function as signal-responsive repressors of the epigenetic program for pathological cardiomyocyte hypertrophy. The conserved deacetylase domains of HDAC5 and HDAC9 are not required for inhibition of cardiac hypertrophy. Thus, the biolo...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Hu, Tianjing, Schreiter, Friederike C., Bagchi, Rushita A., Tatman, Philip D., Hannink, Mark, McKinsey, Timothy A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
Gene Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544848/
https://ncbi.nlm.nih.gov/pubmed/30962285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007006
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