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HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression
Histone deacetylase 5 (HDAC5) and HDAC9 are class IIa HDACs that function as signal-responsive repressors of the epigenetic program for pathological cardiomyocyte hypertrophy. The conserved deacetylase domains of HDAC5 and HDAC9 are not required for inhibition of cardiac hypertrophy. Thus, the biolo...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6544848/ https://ncbi.nlm.nih.gov/pubmed/30962285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007006 |
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