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An effective mouse model for adoptive cancer immunotherapy targeting neoantigens

The adoptive cell transfer (ACT) of T cells targeting mutated neoantigens can cause objective responses in varieties of metastatic cancers, but the development of new T cell–based treatments relies on accurate animal models. To investigate the therapeutic effect of targeting a neoantigen with ACT, w...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Hanada, Ken-ichi, Yu, Zhiya, Chappell, Gabrielle R., Park, Adam S., Restifo, Nicholas P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6542630/
https://ncbi.nlm.nih.gov/pubmed/31092734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124405
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