A Theoretical Physiologically‐Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition

Physiologically‐based pharmacokinetic (PBPK) modeling allows assessment of the covariates contributing to the large pharmacokinetic (PK) variability of tacrolimus; these include multiple physiological and biochemical differences among patients. A PBPK model of tacrolimus was developed, including a v...

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Detaylı Bibliyografya
Yayımlandı:CPT Pharmacometrics Syst Pharmacol
Asıl Yazarlar: Emoto, Chie, Johnson, Trevor N., Hahn, David, Christians, Uwe, Alloway, Rita R., Vinks, Alexander A., Fukuda, Tsuyoshi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6539708/
https://ncbi.nlm.nih.gov/pubmed/30843669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12392
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