A Theoretical Physiologically‐Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition

Physiologically‐based pharmacokinetic (PBPK) modeling allows assessment of the covariates contributing to the large pharmacokinetic (PK) variability of tacrolimus; these include multiple physiological and biochemical differences among patients. A PBPK model of tacrolimus was developed, including a v...

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Bibliografiska uppgifter
I publikationen:CPT Pharmacometrics Syst Pharmacol
Huvudupphovsmän: Emoto, Chie, Johnson, Trevor N., Hahn, David, Christians, Uwe, Alloway, Rita R., Vinks, Alexander A., Fukuda, Tsuyoshi
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2019
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6539708/
https://ncbi.nlm.nih.gov/pubmed/30843669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12392
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