A Theoretical Physiologically‐Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition

Physiologically‐based pharmacokinetic (PBPK) modeling allows assessment of the covariates contributing to the large pharmacokinetic (PK) variability of tacrolimus; these include multiple physiological and biochemical differences among patients. A PBPK model of tacrolimus was developed, including a v...

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Enregistré dans:
Détails bibliographiques
Publié dans:CPT Pharmacometrics Syst Pharmacol
Auteurs principaux: Emoto, Chie, Johnson, Trevor N., Hahn, David, Christians, Uwe, Alloway, Rita R., Vinks, Alexander A., Fukuda, Tsuyoshi
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2019
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6539708/
https://ncbi.nlm.nih.gov/pubmed/30843669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12392
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