Simultaneous Determination of Bufalin and Its Nine Metabolites in Rat Plasma for Characterization of Metabolic Profiles and Pharmacokinetic Study by LC–MS/MS

Characterization and determination of metabolites to monitor metabolic pathways play a paramount role in evaluating the efficacy and safety of medicines. However, the separation and quantification of metabolites are rather difficult due to their limited contents in vivo, especially in the case of Ch...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Wei, Wenlong, Yu, Yang, Wang, Xia, Yang, Linhui, Zhang, Hang, Ji, Hongjian, Li, Zhenwei, Hou, Jinjun, Wu, Wanying, Guo, Dean
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6539458/
https://ncbi.nlm.nih.gov/pubmed/31035327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24091662
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