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Simultaneous determination of dihydrotestosterone and its metabolites in mouse sera by LC-MS/MS with chemical derivatization
Androgens play a vital role in prostate cancer development, and their elimination and blockade are essential in the disease management. DHT is the key ligand for androgen receptor (AR) in the prostate. It is locally synthesized from testosterone. In the prostate, DHT is predominantly metabolized to...
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| Veröffentlicht in: | J Chromatogr B Analyt Technol Biomed Life Sci |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6326363/ https://ncbi.nlm.nih.gov/pubmed/29778874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2018.05.008 |
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