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Simultaneous Quantification of Intracellular Lamivudine and Abacavir Triphosphate Metabolites by LC-MS/MS

Nucleoside reverse transcriptase inhibitors (NRTIs) require intracellular phosphorylation to active triphosphate (TP) nucleotide metabolites before they can inhibit the HIV reverse transcriptase. However, monitoring these pharmacologically active TP metabolites is challenging due to their instabilit...

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Bibliografski detalji
Izdano u:J Pharm Biomed Anal
Glavni autori: Gautam, Nagsen, Lin, Zhiyi, Banoub, Mary G, Smith, Nathan A, Maayah, Audai, McMillan, JoEllyn, Gendelman, Howard E, Alnouti, Yazen
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860827/
https://ncbi.nlm.nih.gov/pubmed/29518644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2018.02.036
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