Simultaneous Quantification of Intracellular Lamivudine and Abacavir Triphosphate Metabolites by LC-MS/MS

Nucleoside reverse transcriptase inhibitors (NRTIs) require intracellular phosphorylation to active triphosphate (TP) nucleotide metabolites before they can inhibit the HIV reverse transcriptase. However, monitoring these pharmacologically active TP metabolites is challenging due to their instabilit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Pharm Biomed Anal
Main Authors: Gautam, Nagsen, Lin, Zhiyi, Banoub, Mary G, Smith, Nathan A, Maayah, Audai, McMillan, JoEllyn, Gendelman, Howard E, Alnouti, Yazen
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860827/
https://ncbi.nlm.nih.gov/pubmed/29518644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2018.02.036
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados