Simultaneous Quantification of Intracellular Lamivudine and Abacavir Triphosphate Metabolites by LC-MS/MS

Nucleoside reverse transcriptase inhibitors (NRTIs) require intracellular phosphorylation to active triphosphate (TP) nucleotide metabolites before they can inhibit the HIV reverse transcriptase. However, monitoring these pharmacologically active TP metabolites is challenging due to their instabilit...

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Bibliografiska uppgifter
I publikationen:J Pharm Biomed Anal
Huvudupphovsmän: Gautam, Nagsen, Lin, Zhiyi, Banoub, Mary G, Smith, Nathan A, Maayah, Audai, McMillan, JoEllyn, Gendelman, Howard E, Alnouti, Yazen
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860827/
https://ncbi.nlm.nih.gov/pubmed/29518644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2018.02.036
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