Simultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC–ESI–MS/MS: An application for pharmacokinetic studies

Hydroxychloroquine (HCQ) has been shown to disrupt autophagy and sensitize cancer cells to radiation and chemotherapeutic agents. However, the optimal delivery method, dose, and tumor concentrations required for these effects are not known. This is in part due to a lack of sensitive and reproducible...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Chromatogr B Analyt Technol Biomed Life Sci
Prif Awduron: Chhonker, Yashpal S., Sleightholm, Richard L, Li, Jing, Oupický, David, Murry, Daryl J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786170/
https://ncbi.nlm.nih.gov/pubmed/29207305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2017.11.026
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