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Simultaneous quantitation of hydroxychloroquine and its metabolites in mouse blood and tissues using LC–ESI–MS/MS: An application for pharmacokinetic studies

Hydroxychloroquine (HCQ) has been shown to disrupt autophagy and sensitize cancer cells to radiation and chemotherapeutic agents. However, the optimal delivery method, dose, and tumor concentrations required for these effects are not known. This is in part due to a lack of sensitive and reproducible...

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Veröffentlicht in:J Chromatogr B Analyt Technol Biomed Life Sci
Hauptverfasser: Chhonker, Yashpal S., Sleightholm, Richard L, Li, Jing, Oupický, David, Murry, Daryl J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5786170/
https://ncbi.nlm.nih.gov/pubmed/29207305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2017.11.026
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