FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

Telomerase negative immortal cancer cells elongate telomeres through the Alternative Lengthening of Telomeres (ALT) pathway. While sustained telomeric replicative stress is required to maintain ALT, it might also lead to cell death when excessive. Here, we show that the ATPase/translocase activity o...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Silva, Bruno, Pentz, Richard, Figueira, Ana Margarida, Arora, Rajika, Lee, Yong Woo, Hodson, Charlotte, Wischnewski, Harry, Deans, Andrew J., Azzalin, Claus M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538666/
https://ncbi.nlm.nih.gov/pubmed/31138795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10179-z
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