FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

Telomerase negative immortal cancer cells elongate telomeres through the Alternative Lengthening of Telomeres (ALT) pathway. While sustained telomeric replicative stress is required to maintain ALT, it might also lead to cell death when excessive. Here, we show that the ATPase/translocase activity o...

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Publicado en:Nat Commun
Autores principales: Silva, Bruno, Pentz, Richard, Figueira, Ana Margarida, Arora, Rajika, Lee, Yong Woo, Hodson, Charlotte, Wischnewski, Harry, Deans, Andrew J., Azzalin, Claus M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538666/
https://ncbi.nlm.nih.gov/pubmed/31138795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10179-z
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