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TRF1 participates in chromosome end protection by averting TRF2-dependent telomeric R-loops
The shelterin protein TRF2 assembles protective T-loops at chromosome ends by stimulating intramolecular invasion of the telomeric G-rich ssDNA overhang into the duplex telomeric array. The other shelterin factor TRF1 is thought to mainly facilitate telomeric dsDNA replication without directly parti...
Shranjeno v:
| izdano v: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5808845/ https://ncbi.nlm.nih.gov/pubmed/29358759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-017-0021-5 |
| Oznake: |
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