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RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells
A fraction of cancer cells maintain telomeres through the telomerase-independent, ‘Alternative Lengthening of Telomeres’ (ALT) pathway. ALT relies on homologous recombination (HR) between telomeric sequences; yet, what makes ALT telomeres recombinogenic remains unclear. Here we show that the RNA end...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4218956/ https://ncbi.nlm.nih.gov/pubmed/25330849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6220 |
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