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TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells
Alternative Lengthening of Telomeres (ALT) is a Break-Induced Replication (BIR)-based mechanism elongating telomeres in a subset of human cancer cells. While the notion that spontaneous DNA damage at telomeres is required to initiate ALT, the molecular triggers of this physiological telomere instabi...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8213692/ https://ncbi.nlm.nih.gov/pubmed/34145295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24097-6 |
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