RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

A fraction of cancer cells maintain telomeres through the telomerase-independent, ‘Alternative Lengthening of Telomeres’ (ALT) pathway. ALT relies on homologous recombination (HR) between telomeric sequences; yet, what makes ALT telomeres recombinogenic remains unclear. Here we show that the RNA end...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Arora, Rajika, Lee, Yongwoo, Wischnewski, Harry, Brun, Catherine M., Schwarz, Tobias, Azzalin, Claus M.
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218956/
https://ncbi.nlm.nih.gov/pubmed/25330849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6220
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