Minimally toxic dose of lipopolysaccharide and α-Synuclein oligomer elicit synergistic dopaminergic neurodegeneration: role and mechanism of microglial NOX2 activation

OBJECTIVES: To investigate role and mechanism of microglial β-nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) activation in minimally toxic dose of lipopolysaccharide (LPS) and α-Synuclein (Syn)-elicited synergistic dopaminergic neurodegeneration. EXPERIMENTAL DESIGN OF THE PAPER: NOX2(...

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Dettagli Bibliografici
Pubblicato in:Mol Neurobiol
Autori principali: Zhang, Wei, Gao, Jun-hua, Yan, Zhao-fen, Huang, Xi-yan, Guo, Peng, Sun, Li, Liu, Zhuo, Hu, Yang, Zuo, Li-jun, Yu, Shu-yang, Cao, Chen-Jie, Wang, Xiao-min, Hong, Jau-shyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6538260/
https://ncbi.nlm.nih.gov/pubmed/27975175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-016-0308-2
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