Identification of the IL-33 protein segment that controls subcellular localization, extracellular secretion, and functional maturation

Proteolytic activation of the IL-33 precursor, full-length interleukin-33 (FLIL33), at multiple sites within the sensor domain (aa 95 – 109) yields several functionally mature (MIL33) forms. Unlike nuclear FLIL33, intracellular MIL33 occurs in the cytoplasm, is secreted from source cells, and exerts...

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Detalhes bibliográficos
Publicado no:Cytokine
Main Authors: Luzina, Irina G., Clerman, Andrew, Fishelevich, Rita, Todd, Nevins W., Lockatell, Virginia, Atamas, Sergei P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535307/
https://ncbi.nlm.nih.gov/pubmed/30856600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2019.02.015
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