Generation of hypoimmunogenic human pluripotent stem cells

Polymorphic HLAs form the primary immune barrier to cell therapy. In addition, innate immune surveillance impacts cell engraftment, yet a strategy to control both, adaptive and innate immunity, is lacking. Here we employed multiplex genome editing to specifically ablate the expression of the highly...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Han, Xiao, Wang, Mengning, Duan, Songwei, Franco, Paul J., Kenty, Jennifer Hyoje-Ryu, Hedrick, Preston, Xia, Yulei, Allen, Alana, Ferreira, Leonardo M. R., Strominger, Jack L., Melton, Douglas A., Meissner, Torsten B., Cowan, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535035/
https://ncbi.nlm.nih.gov/pubmed/31040209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902566116
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