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Genome-Edited Human Pluripotent Stem Cell-Derived Macrophages as a Model of Reverse Cholesterol Transport—Brief Report

OBJECTIVE: To create isogenic human pluripotent stem cell-derived macrophages with and without ABCA1 expression as a model for reverse cholesterol transport. APPROACH AND RESULTS: The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) genome-editing system...

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Dettagli Bibliografici
Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Gupta, Rajat M., Meissner, Torsten B., Cowan, Chad A., Musunuru, Kiran
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690765/
https://ncbi.nlm.nih.gov/pubmed/26543098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.305956
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