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Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment

Genomic DNA in eukaryotes is organized into chromatin through association with core histones to form nucleosomes, each distinguished by their DNA sequences and histone variants. Here, we used a single-chain antibody fragment (scFv) derived from the anti-nucleosome antibody mAb PL2-6 to stabilize hum...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Zhou, Bing-Rui, Yadav, K. N. Sathish, Borgnia, Mario, Hong, Jingjun, Cao, Baohua, Olins, Ada L., Olins, Donald E., Bai, Yawen, Zhang, Ping
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534667/
https://ncbi.nlm.nih.gov/pubmed/31127102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10247-4
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