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Atomic resolution cryo-EM structure of a native-like CENP-A nucleosome aided by an antibody fragment
Genomic DNA in eukaryotes is organized into chromatin through association with core histones to form nucleosomes, each distinguished by their DNA sequences and histone variants. Here, we used a single-chain antibody fragment (scFv) derived from the anti-nucleosome antibody mAb PL2-6 to stabilize hum...
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| Publicat a: | Nat Commun |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6534667/ https://ncbi.nlm.nih.gov/pubmed/31127102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10247-4 |
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