Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer

BACKGROUND: In non-small cell lung cancer (NSCLC), PD-L1 expression on either tumor cells (TC) or both TC and tumor-infiltrating immune cells (IC) is currently the most used biomarker in cancer immunotherapy. However, the mechanisms involved in PD-L1 regulation are not fully understood. To provide b...

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Udgivet i:PLoS One
Main Authors: Theelen, Willemijn S. M. E., Kuilman, Thomas, Schulze, Katja, Zou, Wei, Krijgsman, Oscar, Peters, Dennis D. G. C., Cornelissen, Sten, Monkhorst, Kim, Sarma, Pranamee, Sumiyoshi, Teiko, Amler, Lukas C., Willems, Stefan M., Blaauwgeers, Johannes L. G., van Noesel, Carel J. M., Peeper, Daniel S., van den Heuvel, Michel M., Kowanetz, Marcin
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534376/
https://ncbi.nlm.nih.gov/pubmed/31125352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216864
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