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Phenotypic diversity drives paracrine drug tolerance

Considerable clinical successes have been achieved in cancer treatment since the introduction of targeted therapies. However, almost inevitably tumors develop therapy resistance, which limits durable clinical responses. Tumors are often heterogeneous, and as a result, therapy‐resistant cells are pre...

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Bibliographic Details
Published in:EMBO Mol Med
Main Authors: Kuilman, Thomas, Peeper, Daniel S
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538330/
https://ncbi.nlm.nih.gov/pubmed/28694322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707956
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