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Phenotypic diversity drives paracrine drug tolerance

Considerable clinical successes have been achieved in cancer treatment since the introduction of targeted therapies. However, almost inevitably tumors develop therapy resistance, which limits durable clinical responses. Tumors are often heterogeneous, and as a result, therapy‐resistant cells are pre...

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Detalles Bibliográficos
Publicado en:EMBO Mol Med
Main Authors: Kuilman, Thomas, Peeper, Daniel S
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538330/
https://ncbi.nlm.nih.gov/pubmed/28694322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707956
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