Cancer Drug Addiction is Relayed by an ERK2-Dependent Phenotype Switch

Drug addiction denotes the dependency of tumors on the same therapeutic drugs to which they have acquired resistance. Observations from cultured cells1–3, animal models4 and patients5–7 raise the possibility that cancer drug addiction can instigate a potential cancer vulnerability, which may be used...

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Publicado en:Nature
Autores principales: Kong, Xiangjun, Kuilman, Thomas, Shahrabi, Aida, Boshuizen, Julia, Kemper, Kristel, Song, Ji-Ying, Niessen, Hans W.M., Rozeman, Elisa A., Geukes Foppen, Marnix H., Blank, Christian U., Peeper, Daniel S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640985/
https://ncbi.nlm.nih.gov/pubmed/28976960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature24037
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