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Phenotypic diversity drives paracrine drug tolerance

Considerable clinical successes have been achieved in cancer treatment since the introduction of targeted therapies. However, almost inevitably tumors develop therapy resistance, which limits durable clinical responses. Tumors are often heterogeneous, and as a result, therapy‐resistant cells are pre...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Kuilman, Thomas, Peeper, Daniel S
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538330/
https://ncbi.nlm.nih.gov/pubmed/28694322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707956
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