Paracrine Wnt5a-β-catenin Signaling Triggers a Metabolic Program That Drives Dendritic Cell Tolerization

Despite recent advances, many cancers remain refractory to available immunotherapeutic strategies. Emerging evidence indicates that the tolerization of local dendritic cells (DCs) within the tumor microenvironment promotes immune evasion. Here we have described a mechanism by which melanomas establi...

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Veröffentlicht in:Immunity
Hauptverfasser: Zhao, Fei., Xiao, Christine, Evans, Kathy S., Theivanthiran, Tbalamayooran, DeVito, Nicholas, Holtzhausen, Alisha, Liu, Juan, Liu, Xiaojing, Boczkowski, David, Nair, Smita, Locasale, Jason W., Hanks, Brent A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777287/
https://ncbi.nlm.nih.gov/pubmed/29343435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.12.004
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