Paracrine Wnt5a-β-catenin Signaling Triggers a Metabolic Program That Drives Dendritic Cell Tolerization

Despite recent advances, many cancers remain refractory to available immunotherapeutic strategies. Emerging evidence indicates that the tolerization of local dendritic cells (DCs) within the tumor microenvironment promotes immune evasion. Here we have described a mechanism by which melanomas establi...

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Publicado en:Immunity
Autores principales: Zhao, Fei., Xiao, Christine, Evans, Kathy S., Theivanthiran, Tbalamayooran, DeVito, Nicholas, Holtzhausen, Alisha, Liu, Juan, Liu, Xiaojing, Boczkowski, David, Nair, Smita, Locasale, Jason W., Hanks, Brent A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777287/
https://ncbi.nlm.nih.gov/pubmed/29343435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.12.004
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