Melnoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy

The β-catenin signaling pathway has been demonstrated to promote the development of a tolerogenic dendritic cell (DC) population capable of driving regulatory T-cell (Treg) differentiation. Further studies have implicated tolerogenic DCs in promoting carcinogenesis in preclinical models. The molecul...

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Vydáno v:Cancer Immunol Res
Hlavní autoři: Holtzhausen, Alisha, Zhao, Fei, Evans, Kathy S., Tsutsui, Masahito, Orabona, Ciriana, Tyler, Douglas S., Hanks, Brent A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927300/
https://ncbi.nlm.nih.gov/pubmed/26041736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0167
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