Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy

While immune checkpoint blockade is associated with prolonged responses in multiple cancers, most patients still do not benefit from this therapeutic strategy. The Wnt-β-catenin pathway is associated with diminished T cell infiltration; however, activating mutations are rare, implicating a role for...

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Veröffentlicht in:Cell Rep
Hauptverfasser: DeVito, Nicholas C., Sturdivant, Michael, Thievanthiran, Balamayooran, Xiao, Christine, Plebanek, Michael P., Salama, April K.S., Beasley, Georgia M., Holtzhausen, Alisha, Novotny-Diermayr, Veronica, Strickler, John H., Hanks, Brent A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8148423/
https://ncbi.nlm.nih.gov/pubmed/33951424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109071
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