Paracrine Wnt5a-β-catenin Signaling Triggers a Metabolic Program That Drives Dendritic Cell Tolerization

Despite recent advances, many cancers remain refractory to available immunotherapeutic strategies. Emerging evidence indicates that the tolerization of local dendritic cells (DCs) within the tumor microenvironment promotes immune evasion. Here we have described a mechanism by which melanomas establi...

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Bibliografiske detaljer
Udgivet i:Immunity
Main Authors: Zhao, Fei., Xiao, Christine, Evans, Kathy S., Theivanthiran, Tbalamayooran, DeVito, Nicholas, Holtzhausen, Alisha, Liu, Juan, Liu, Xiaojing, Boczkowski, David, Nair, Smita, Locasale, Jason W., Hanks, Brent A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5777287/
https://ncbi.nlm.nih.gov/pubmed/29343435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.12.004
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