Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer

BACKGROUND: In non-small cell lung cancer (NSCLC), PD-L1 expression on either tumor cells (TC) or both TC and tumor-infiltrating immune cells (IC) is currently the most used biomarker in cancer immunotherapy. However, the mechanisms involved in PD-L1 regulation are not fully understood. To provide b...

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Publicado no:PLoS One
Main Authors: Theelen, Willemijn S. M. E., Kuilman, Thomas, Schulze, Katja, Zou, Wei, Krijgsman, Oscar, Peters, Dennis D. G. C., Cornelissen, Sten, Monkhorst, Kim, Sarma, Pranamee, Sumiyoshi, Teiko, Amler, Lukas C., Willems, Stefan M., Blaauwgeers, Johannes L. G., van Noesel, Carel J. M., Peeper, Daniel S., van den Heuvel, Michel M., Kowanetz, Marcin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6534376/
https://ncbi.nlm.nih.gov/pubmed/31125352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216864
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